In studying the largest objects in the universe (like stars) and the smallest (like quarks), you will find what is true in one scale is not on another.

So the simplest example is gravity. Gravity on earth shows objects falling at the same rate. That is inconsistent in space.

There is an metaphor here:

The friction we have with people often has to do with scale. We are too focused in and lose the big picture. And it can be easy to hang in the clouds while skipping the details too.

Perhaps then, when we approach solving really difficult problems, we should address the scale we are going to use. Do we need to see this from the 30,000 foot view or do we need a microscope?